Since we've been building all our sites with a mobile first, RWD approach (love @malarkey's 320andUp!!), I've found the more tangible, textured and graphically heavy aesthetic has been a lot harder to scale up, as well as being frankly inappropriate across screen sizes.
I've found (for myself at least), that the move to design in the browser and (rightly so) focus on content and cut out the excess has lead to site designs that have the danger of becoming dull and lacking the "wow" factor that previously would've borrowed heavily on a very visually rich style.
Have other people found this, and how have you overcome it?